Exosomes generated from cancer cells, being charged with oncogenic molecules, induce the secretion of immune mediators such as IL-6, IL-10, CXCR4, and C-C Motif Chemokine Ligand 2 (CCL2), and subsequently lead to TAM-like phenotype transition, while their stimulation is insufficient to generate macrophage polarization to either M1 or M2 phenotype (53). The gene discussed is CCL2; the disease is cancer.