Of note, we found that stroke patients with larger infarct volume have more severe loss of NK cell number (r = −0.655, p = 0.0017) and expression of CD69 (r = −0.757, p = 0.0001), NKG2D (r = −0.668, p = 0.0013), IFN-γ (r = −0.659, p = 0.0016), CD27 (r = −0.574, p = 0.0081), and Perforin (r = −0.616, p = 0.038) after stroke onset (Figures 2A–F). This evidence concerns the gene PRF1 and Stroke.