As already reported (13), despite the lack of any pharmacological post-transplant prophylaxis, in our study the incidence of both acute and chronic GvHD was limited (with no patient experiencing grade III-IV acute or extensive chronic GvHD), much lower than that of other similar case series (47) or other type of graft manipulation, such as CD3/CD19-depletion (48). The gene discussed is CD19; the disease is graft versus host disease.