It has been shown that nitrogen-containing bisphosphonates, such as zoledronic acid, cause the inhibition of farnesyl diphosphate synthase in tumor cell lines, which leads to the accumulation of isopentenyl pyrophosphate (IPP), a type of non-peptidic-phosphorylated metabolite (nPAgs), which indirectly activates γδ T cell (41, 42). Here, FDPS is linked to neoplasm.