In non-small-cell lung carcinomas (NSCLCs), B7-H3-negative tumors demonstrated abundant CD8+ TIL infiltration, and an anti-B7-H3 antibody combined with anti-PD-1 antibody therapy showed potent antitumor activation in a Pan02 murine NSCLC model (35). This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.