Evidence has shown that B7-H3 upregulated Smad1 expression via the PI3K-Akt pathway (14), downregulated the expression of β-catenin and E-cadherin, and increased the expression of vimentin and N-cadherin, indicating that B7-H3 promotes EMT in CRC (39). The gene discussed is CD276; the disease is colorectal carcinoma.