AKT1 and colorectal carcinoma: In addition, CRC cell-overexpressed B7-H3 upregulated the expression of X-ray repair cross-complementing group 1 (XRCC1) via the PI3K-AKT pathway and BRCA1/BRCA2-containing complex subunit 3 (BRCC3), which then repaired oxaliplatin (L-OHP) or 5-fluorouracil (5-FU)-induced DNA damage (42, 43).