PTPN22 and goiter: Younger age <40 yrs, higher serum fT4 level >40 pmol/l, higher serum TBII titre, larger goiter size at diagnosis, and genetic factors including PTPN22 C/T polymorphisms, and HLA subtypes DQB1*02, DQA1*05, and DRB1*03 were independent risk predictors for recurrence (48).