On the other hand, anabolic hormones, insulin-like growth factor-1 (IGF-1), dehydroepiandrosterone-sulfate (DHEA-S), testosterone (T), have an important role on cardiac morphology and function (19–21); Anabolic hormones deficiency, in which the so called “cardiac cachexia” represents the end-stage, demonstrated detrimental impact on disease progression and mortality in heart failure with reduced ejection fraction (HFrEF) (22–24). The gene discussed is IGF1; the disease is heart failure.