IL1B and hyperthyroidism: IL-1β secreted by peripheral monocytes induces IL-6 secretion by stromal cells and osteoblast, IL-6 increments osteoclast proliferation and differentiation inducing increased bone resorption (110) A role of IL-1β hypersecretion cannot be excluded as a potential mediator of hyperthyroidism associated altered bone resorption (111).