In the last few years, the conformational sensitive MOG-IgG antibodies have been widely studied mainly due to it is association to CNS inflammatory injuries such as ADEM, ON, TM, pediatric demyelinating disorders, AQP4-seronegative NMOSD and NMDAR encephalitis with overlapping demyelinating syndromes (132, 133). The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.