Another meta-analysis of GWASs identified the Membrane-associated guanylate kinase inverted repeat member 1 (MAGI1) gene as a novel locus for neuroticism, both among the entire cohort of 63,661 individuals as well as in the combined Netherlands Twin Registry (NTR)/Netherlands Study of Depression and Anxiety (NESDA) cohort, with significant polygenic risk scores associated with MDD for SNP sets at P-value thresholds of 0.01 and 0.05, again providing compelling evidence that higher neuroticism is strongly correlated with MDD (183). This evidence concerns the gene MAGI1 and major depressive disorder.