Moreover, carriers of PSEN1 mutations could develop frontotemporal dementia, dementia with Lewy bodies, Pick’s disease, amyotrophic lateral sclerosis, Parkinsonism, spastic paraparesis, cerebral amyloid angiopathy, and corticobasal syndrome (Supplementary Table 2, according to the data from the website www.alzforum.org). Here, PSEN1 is linked to frontotemporal dementia.