Moreover, carriers of PSEN1 mutations could develop frontotemporal dementia, dementia with Lewy bodies, Pick’s disease, amyotrophic lateral sclerosis, Parkinsonism, spastic paraparesis, cerebral amyloid angiopathy, and corticobasal syndrome (Supplementary Table 2, according to the data from the website www.alzforum.org). The gene discussed is PSEN1; the disease is Spastic paraparesis.