PSEN1 and Alzheimer disease: Several PSEN1 mutants (p.I83T, p.L113P, p.M139V, p.M139T, p.W165C, p.L166R, p.E184G, p.P264L, p.R269H, p.R278I, p.E280G, p. [S290C; T291_S319del], p.P355S) have been associated with non-amnestic AD (10, 22–26).