FLT4 and lymphedema: Two separate mouse models of impaired VEGFR-3 signaling, the Chy (Karkkainen et al., 2001) and K14-VEGFR-3-Ig (Makinen et al., 2001), are both characterized by lack of dermal lymphatic capillaries and presence of lymphedema, but the skin of Chy mice consisted of higher deposition of collagen and fat (Rutkowski et al., 2010).