PROX1 and obesity due to melanocortin 4 receptor deficiency: Furthermore, it was demonstrated that perilymphatic inflammatory cell accumulation may contribute to lymphatic dysfunction and the pathogenesis of obesity via loss of LEC identity as gene expression of VEGFR-3, Prox1, and CCL21 was reduced in LECs isolated from sedentary, obese mice compared to lean controls (Hespe et al., 2016).