Additionally, individuals suffering from hereditary lymphedema associated with mutations in transcription factors such as FOXC2 contributing to the development of lymphedema-distichiasis, or GATA2 contributing to the development Emberger syndrome (Mansour et al., 2010; Ostergaard et al., 2011), may be at risk for abnormal adipose deposition and development of obesity due to proliferation and hypertrophy of adipocytes in lymphedematous tissues (Zampell et al., 2012a; Mehrara and Greene, 2014). The gene discussed is FOXC2; the disease is obesity due to melanocortin 4 receptor deficiency.