• Delayed lipoprotein clearance• Development of hyper- and dyslipoproteinemia• Development of severe hypercholesterolemia• Prone to development of atherosclerotic lesions• Enlarged initial lymphatic vessels, with decreased lymphatic muscle cell coverage and abnormal distribution of LYVE-1• Lymphatic leakiness and decreased transport of fluid and dendritic cells• Impaired lymphatic drainage required for reverse cholesterol transport. This evidence concerns the gene LYVE1 and familial hypercholesterolemia.