These and other works have provided reports of stem cell lines with DCM-associated mutations including RBM20 (Wyles et al., 2016a), PLB (Karakikes et al., 2015), EMD (Shimojima et al., 2017), or CSRP3 (Li et al., 2019), showing marked calcium handling abnormalities that may recapitulate the early myocardial alterations occurring in human DCM hearts. This evidence concerns the gene CSRP3 and familial dilated cardiomyopathy.