PLN and familial dilated cardiomyopathy: Early onset DCM with lethal ventricular arrhythmias. Low QRS complex potentials and decreased R wave amplitude, negative T waves in left precordial leads (Hof et al., 2019). PLN R14del mutation associated with high risk for malignant arrhythmias and end-stage HF from late adolescence, can cause either a DCM phenotype or ARVC (Mestroni et al., 2014).A milder phenotype is also reported (DeWitt et al., 2006).