HSPA5 and Alzheimer disease: Data indicated that icariin reduced neuronal apoptosis and suppressed ERS signaling including decreased the level of GRP78, phosphorylated ER-regulated kinase and phosphorylated eIF2α, as well ATF4, CHOP, DNA damage inducible protein 34 and tribbles homologous protein 3 to protect against Alzheimer’s disease animal model (Li et al., 2019).