Osteoporosis is also considered a chronic inflammatory disease, as several increased proinflammatory cytokines, including tumor necrosis factor (TNF-α), interleukin (IL)-1β, and IL-6, may regulate RANKL expression (Zhao et al., 2016; Michalski and McCauley, 2017; Zeng et al., 2019). The gene discussed is TNF; the disease is osteoporosis.