In this context, it should be noticed that quinolinate phosphoribosyltransferase (QPRT), which belongs to the phosphoribosyltransferase family and is involved in de novo NAD biosynthesis using quinolinic acid (QA) as a precursor in both prokaryotes and eukaryotes, has not been thoroughly investigated in the context of cancer and inflammation, but there are evidences that also this enzyme might play a role (Hinsch et al., 2009; Sahm et al., 2013; Ullmark et al., 2017; Haslinger et al., 2018). This evidence concerns the gene QPRT and cancer.