P2RX7 and Sepsis: In the same study, the murine CLP model was used to test the role of activation of P2X7 in vivo prior to induction of sepsis and the authors documented an increased mortality (Martinez-Garcia et al., 2019) However, opposing studies using the murine model suggest that P2X7 could be protective within sepsis and demonstrated increased mortality in P2X7-/- mice (Csoka et al., 2015).