In various models of disease IVM-dependent increased P2X4 activity might affect alcohol intake, sensorimotor gating, and dopamine-induced motor behavior (Bortolato et al., 2013; Khoja et al., 2016; Khoja et al., 2018; Khoja et al., 2019) implicating P2X4 as a novel drug target for the treatment of alcoholism and psychiatric disorders. The gene discussed is P2RX4; the disease is alcohol dependence.