P2X7 has been demonstrated to provide immune protection towards viral (dengue), bacterial (chlamydia, periodontitis, tuberculosis), fungal (paracoccidioidomycosis), parasitic (leishmaniasis, trypanosomiasis, toxoplasmosis, amoebiasis, malaria), and helminth (schistosomiasis) infections. The gene discussed is P2RX7; the disease is periodontitis.