HTR2C and post-traumatic stress disorder: In particular, PTSD patients have exaggerated stress response to a 5-HT2C agonist (Southwick et al., 1997) and display typical traits of serotonergic alterations including irritability, impulsivity and suicidability, which are themselves associated with 5-HT2C receptor upregulation and altered 5-HT2C mRNA splicing and editing (Niswender et al., 2001; Pandey et al., 2006; Di Narzo et al., 2014; Panagioti et al., 2015).