CACNA1C and familial long QT syndrome: It is of interest to note that calcium channels include the structurally homologous family of voltage-gated ion channels, such as CACNA1C-encoded L-type calcium channel (Cav1.2, LTCC), which transports calcium ions into myocytes, regulating the excitation–contraction coupling process, and leading to the development of LQTS phenotype (Estes et al., 2019; Ye et al., 2019).