KCNA5 also encodes hKv1.5, and this genetic alteration increases the electrical activity of cells, therefore, the controlling of hKv1.5 expression and function may result in a proper physiological electrical activity, suggesting that hKv1.5 may be a potential target for the treatment of AF (Xie et al., 2019). Here, KCNA5 is linked to atrial fibrillation.