Several tissues including cardiac myocytes express both HO-1 and HO-2 proteins, and HO-1 expression can be particularly increased by several stress factors (Ewing et al., 1994; Wu et al., 2011; Haines and Tosaki, 2018) including myocardial ischemia/reperfusion (Maulik et al., 1996; Lakkisto et al., 2002) as demonstrated at mRNA and protein levels. This evidence concerns the gene HMOX1 and myocardial ischemia.