Isochlorogenic acid B [extracted from Laggera alata (Asteraceae)] shows its protective effects on fibrosis in NASH by Nrf2 signaling pathway, and reverse the downregulation of miR-122 level and upregulation of hepatic HIF-1α expression to inhibit multiple profibrogenic factors (COL1α1, MCP-1, LOX, TGF-β1, and TIMP-1) (Liu et al., 2019c). Here, HIF1A is linked to metabolic dysfunction-associated steatohepatitis.