HMOX1 and metabolic dysfunction-associated steatotic liver disease: The down-regulation of hepatic HO-1, NF-E2-related factor 2 (Nrf2), and SOD2 as well as up-regulation KEAP1 were detected in the NAFLD models, and the expression of these oxidative stress markers can be all reversed by Dioscin (Liu et al., 2015b).