Naringenin (Mulvihill et al., 2009), Ginsenoside Rb1(Yu et al., 2015) and Leonurus japonicus Houtt extract (Lee et al., 2017) prevented hyperinsulinemia, leading to the correction of NAFLD associated metabolic disturbance that was linked to glucose utilization and insulin sensitivity (Lee et al., 2017). The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.