Resveratrol can be considered as a pharmacological SIRT1 activator (Zhang et al., 2015) and take effects on hepatic steatosis by improving lipid-related gene transcriptional expression, oxidative stress and inflammation (Cheng et al., 2019), meanwhile decreasing ER stress (Ding et al., 2017) via the autophagy (Liu et al., 2015a). This evidence concerns the gene SIRT1 and fatty liver disease.