CYP7A1 and metabolic dysfunction-associated steatotic liver disease: Gypenosides (extracted from Gynostemma pentaphyllum) (Li et al., 2017a), palmatine and jatrorrhizine (extracted from Coptidis Rhizoma) promote bile acid synthesis to prevent NAFLD, which involved the expression of cholesterol 7α-hydroxylase A1 (CYP7A1).