These have been supported by the evidence that total aralosides from aralia elata (Miq) seem protected mice against HFD-induced cellular apoptosis, as suggested by TUNEL staining, and ameliorated NASH by inhibiting the NF-κB/IRE1α/JNK/IκB activation in ApoE-/- mice (Luo et al., 2015); Lycium barbarum polysaccharides partially modulated hepatocyte apoptosis process via NF-κB/MAPK pathways, which has been proved to be related to the biological activity of l-arabinose and β-carotene in polysaccharides (Xiao et al., 2014). The gene discussed is MAPK8; the disease is metabolic dysfunction-associated steatohepatitis.