Notably, the mRNA level of the FXR target genes FGF15, SHP, and iBABP in ileum, and organic solute transporter (OST) β in liver were all significantly upregulated in ob/ob mice administered with vidofludimus (Figures 6E, F), suggesting the effects of vidofludimus on NAFLD is through targeting FXR. This evidence concerns the gene FABP6 and metabolic dysfunction-associated steatotic liver disease.