The down-regulation of sterol regulatory element binding protein-1c (SREBP-1c) and carbohydrate responsive element binding protein (ChREBP), two major mediators of lipogenic gene expression (Dentin et al., 2005), in liver tissues of vidofludimus-treated mice (Figure 6E), further provided the molecular mechanisms of vidofludimus on hepatic steatosis amelioration in ob/ob mice. This evidence concerns the gene SREBF1 and Hepatic steatosis.