Matrine derivatives (6aS, 10S, 11aR, 11bR, 11cS)-10-methylamino-dodecahydro-3a, 7a-diazabenzo (de) (MASM) can inhibit the proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells through PI3K/AKT/mTOR and AKT/GSK3β/β-catenin signaling pathways, inhibit the growth of tumors and inhibit the dryness of tumor cells (Liu Y. et al., 2017). Here, GSK3B is linked to hepatocellular carcinoma.