Studies have shown that matrine upregulates gadd45b expression via p38/JNK, ROS/gadd45b/p38 pathway, inhibits proliferation and migration of prostate cancer DU145, PC3 cells, and induces apoptosis (Huang et al., 2018), which is also associated with NF-κB pathway (Li Q. et al., 2016). This evidence concerns the gene GADD45B and Familial prostate cancer.