Matrine can regulate noncoding RNA and then affect key molecules related to cancer progression, such as upregulation of miR-126 to inhibit VEGF (An et al., 2016), downregulation of miR-21 and miR-19b-3p, and alleviate the inhibition of PTEN (Lin et al., 2014; Wei Y. et al., 2018). Here, PTEN is linked to cancer.