CDKN1A and acute lymphoblastic leukemia: Matrine can inhibit the expression of hsa-mir-106 b-3p and upregulate the expression of CDKN1A in human acute lymphoblastic leukemia (ALL) cell line CCRF-CEM, thereby blocking the cell cycle at G0/G1 phase and inducing apoptosis (Tetik et al., 2018).