Mahzari et al. (2018) reported that in two models of liver fibrosis with abnormal glucose metabolism induced by high fructose diet (HFRU), high fat diet (HF) and low dose streptozotocin (STZ), matrine intervention can upregulate heat-shock protein 72 (HSP72) to inhibit liver fibrosis and improve blood sugar level. For carbon tetrachloride (CCl4)-treated hepatic stellate cell inflammation and fibrosis models, matrine can inhibit the production of MCP-1 and reduce the infiltration of Gr1(hi) monocytes in liver tissue, reducing liver inflammation and fibrosis (Shi et al., 2013). This evidence concerns the gene CCL2 and Hepatic fibrosis.