Qian et al. reported that WM130, a matrine derivative, could inhibit the proliferation, invasion and migration of HCC cells by inhibiting EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways and induce apoptosis of hepatocellular carcinoma cells (Qian et al., 2015). This evidence concerns the gene PTEN and hepatocellular carcinoma.