PPARG and Schnyder corneal dystrophy: First, we found that HFSD significantly increased Pparγ and Pparγ2 mRNA expression without alteration of Pparγ1 compared with the SCD group, and that the administration of LP533401 to rats fed a TRP-free diet decreased hepatic Pparγ and Pparγ2 gene expression compared with the HFSD group (Figure 4A).