The pathways were ranked as follows: NOD-like receptor signaling pathway, apoptosis, estrogen signaling pathway, prolactin signaling pathway, Cushing’s syndrome, longevity-regulating pathway, progesterone-mediated oocyte maturation, ovarian steroidogenesis, oocyte meiosis, steroid hormone biosynthesis, Th1 and Th2 cell differentiation, GnRH signaling pathway, chemokine signaling pathway, shigellosis, and ECM-receptor interaction (Figure 5B). The gene discussed is GNRH1; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.