CASP1 and rheumatoid arthritis: In addition to NF-κB, the NOD-like receptor protein 3 (NLRP3) inflammasome, which is a multimeric protein complex of NLRP3, apoptosis-associated speck-like protein containing (ASC), and caspase-1 (Wang et al., 2018), is thought to function as a key regulator of RA.