Of the overall cohort, 31 patients without hypertension but with white matter disease (Fazekas scale 2 or 3) were selected and genetically analyzed for NOTCH3 gene mutations in the phase 1 cohort (mean age ± SD, 77.4 ± 9.6 11.0; 76.5% men) (Figure 1). Here, NOTCH3 is linked to hypertensive disorder.