NOTCH3 and ischemic stroke: Lee et al. reported that the NOTCH3 p.R544C mutation was present in a significant number of individuals in Taiwan, including 60 of 7,038 healthy controls (0.9%), 17 of 800 patients with ischemic stroke (2.1%), and 16 of 245 patients with small vessel occlusion stroke (6.5%) from the Taiwan Biobank and that the other two cysteine-altering mutations (p.C853Y, and p.C884Y) were rarely detected (Lee et al., 2020).