In continuity with those earlier findings, and with the scope of evaluating the presence of gender differences as described in human PD, the present study provides new insights into the relevance of A53T transgenic mice as a model of PD, by demonstrating that female mice exhibit a limited PD-like phenotype and dissimilar regional distribution of NCX1 and NCX3 from that previously described in male mice (Sirabella et al., 2018). The gene discussed is SLC8A1; the disease is Parkinson disease.