Amyloid-beta (Aβ) deposition, abnormal tau phosphorylation, and synaptic dysfunction are the characteristic pathological changes of AD (Figure 1; Robakis et al., 1987; Baas and Black, 1990; Wang et al., 1996; Klyubin et al., 2005; Shankar et al., 2008; Kuhn et al., 2010; Martin et al., 2013a, b; Pester et al., 2013; Zhang et al., 2014, 2018; Willem et al., 2015; Roostaei et al., 2017; Kreutzer and Nowick, 2018; Trillaud-Doppia and Boehm, 2018; Baas and Qiang, 2019). The gene discussed is MAPT; the disease is Alzheimer disease.