Given that they can form microscopically prominent extracellular proteopathy, we here name these sortilin fragments as “sorfra(s).” Our initial characterization suggests that this extracellular proteopathy is associated with neuritic-like Aβ plaques, but not with diffuse plaques or subpial and vascular amyloidosis. The gene discussed is SORT1; the disease is proteostasis deficiencies.