DLEU2 and amyotrophic lateral sclerosis: These miRNAs belong to a miR-15/16 cluster in an intronic region of the DLEU2 gene on chromosome 13 and are linked to ALS through profiling peripheral blood, neuron-derived extracellular vesicles, and muscle from ALS subjects (Liguori et al., 2018; Si et al., 2018; Katsu et al., 2019).