TARDBP and amyotrophic lateral sclerosis: Importantly, since cyTDP43 pathology is present in both fALS and sALS (Hardiman et al., 2017), and even a minor increase in TDP43 levels can drive neurodegeneration (Barmada and Finkbeiner, 2010; Barmada et al., 2010; Wegorzewska and Baloh, 2011; Janssens et al., 2013; Weskamp and Barmada, 2018), miRNAs associated with cyTDP43 from either cell line could potentially provide insight into mechanisms underlying miRNA dynamics in ALS.