TARDBP and amyotrophic lateral sclerosis: TDP43 mutations are linked to ALS (Kapeli et al., 2017), and cyTDP43 is a universal histopathological hallmark of postmortem brain and spinal cord tissue from fALS and sALS subjects (Neumann et al., 2006; Zhang et al., 2008; Liu-Yesucevitz et al., 2010).