CD4 and myeloid sarcoma: Viral-induced inflammation (meningitis, encephalitis, and myelitis) reaches its peak at 6 days p.i. Viral titer reduces after day 7 p.i. but viral-induced inflammation initiates more complex adaptive immune responses leading to neuronal degeneration and axonal transection, inducing long-term neurological disorders at 30 days p.i. MS is commonly studied in experimental autoimmune encephalitis (EAE) models which demonstrate that myelin-specific CD4+T cells cause neuroinflammation and subsequent demyelination.