To reveal the roles of MALAT1, NLRP3 and miR-224-5p and their relationship in the T2DM with the OSA model, the expression of MALAT1 and miR-224-5p in normal C57 mice, C57 mice exposed to IH, KKAy mice and KKAy mice exposed to IH was analyzed by qRT-PCR. This evidence concerns the gene MALAT1 and obstructive sleep apnea syndrome.