The protein levels of NLRP3, caspase 1, TNF-α and IL-1β in the tissues of the C57+IH group and the KK group were higher than those of the C57 group, and the protein expression of these inflammatory factors was the highest in the KK+IH group (Figures 1D,E). Here, NLRP3 is linked to isolated hemihyperplasia.