Interestingly, we and others have shown that, only during development, Helios is also present in neuronal cell subtypes in the striatum and hippocampus (Martín-Ibáñez et al., 2012, 2017), which are key affected brain regions in schizophrenia patients (Silbersweig et al., 1995; Yoon et al., 2013). The gene discussed is IKZF2; the disease is schizophrenia.