Accordingly, postmortem samples from schizophrenic patients but not from Alzheimer’s disease patients also display an increase of WDFY1 protein levels in the hippocampus and in the dorso-lateral prefrontal cortex, whereas in He–/– mice we found an increase of WDFY1 in the hippocampus and striatum. Here, WDFY1 is linked to early-onset autosomal dominant Alzheimer disease.