BRAF and melanoma: In an analogous study, the researchers observed that 90 patients with sarcomas without a history of malignant melanoma did not have a BRAF mutation; however, BRAF mutations were present in three of 14 patients with a history of malignant melanoma, suggesting that in a poorly differentiated sarcoma with a history of melanoma, the sarcoma is likely to be melanoma and is going through the process of dedifferentiation.24