In contrast to Lipin 1 deficiency in mice (Langner et al., 1989; Peterfy et al., 2001), human Lipin 1 mutations cause muscle pain and weakness without lipodystrophy (Fawcett et al., 2008; Reue & Dwyer, 2009; Zeharia et al., 2008). The gene discussed is LPIN1; the disease is lipodystrophy.