In the literature, increased levels of metalloproteinases with a role in rearrangement of the ECM [63] and up-regulated levels of combined adhesion molecule ITGAV/ITGB3 integrin [64] were associated with greater invasiveness and susceptibility of sloughed menstrual cells being implanted at ectopic sites in endometriosis. This evidence concerns the gene ITGB3 and endometriosis.