NPPB and hydrops fetalis: Interim hospitalization for worsening HF, ischemic cardiomyopathies, renal impairment, and older age was associated with the reluctance of treating physicians to improve guideline adherence over time, whereas higher N-terminal pro b-type natriuretic peptide (NT-proBNP) and higher systolic blood pressure at baseline favored an improvement in therapy [23].