Although transient activation of the cGAS-MITA axis is essential for host defense to DNA pathogens or aberrant self-DNA, its de-regulation causes sever autoimmune diseases such as systemic lupus erythematosus (SLE), Aicardi-Goutières syndrome, and STING-associated vasculopathy with onset in infancy (SAVI) (Liu et al., 2014; Gray et al., 2015; Xia et al., 2016; An et al., 2017; Hu and Shu, 2019). The gene discussed is CGAS; the disease is autoimmune disease.