Among the biological factors are hyperglycemia, hyperinsulinemia, overproduction of insulin-like growth factor-1 (IGF-1), increased expression of the IGF-1 receptor, and increased secretion of inflammatory cytokines, such as interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) [26]. This evidence concerns the gene TNF and hyperinsulinism.