APOE and Alzheimer disease: However, sequence variations within TOMM40, specifically rs2075650 and rs10524523, were suggested to afford AD risk stratification beyond the effects of the APOE‐ε4 allele, as they showed significant risk differences for AD or related phenotypes on the APOE‐ε3 allele background (Omoumi et al., 2014b; Roses et al., 2010).