MAPT and Alzheimer disease: Indeed, defective mitochondrial quality control induced by deletion of the protease subunit AFG3L2 causes hyperphosphorylation of tau in murine cortical neurons (Kondadi et al., 2014) and loss of axonal mitochondria resulting from ablation of Milton increases tau phosphorylation at an AD‐relevant site (Iijima‐Ando et al., 2012).