PICALM and Alzheimer disease: Significant differences in Minor allele frequency (p < .05, uncorrected) were seen for CR1 (rs1408077; OR, 1.59; 95% CI, 1.01–2.49), PICALM (rs541458; OR, 0.68, 95% CI, 0.47–0.98), TOMM40 (rs2075650; OR, 4.30; 95% CI, 2.61–7.06); and possession of 1 or more APOE ε4 alleles (OR, 9.84; 95% CI, 5.48–17.67) using CSF to replicate genetic associations in AD (Schott, 2012).