It is plausible that targeted blood transfusion to increase blood oxygen carrying capacity especially to the brain, oxygen supplementation,37 use of anti‐PD‐1/PD‐L1 antagonists (PD‐1/PD‐L1 blockers) and adjunct therapy to decrease immune activation in combination with standard antifungal treatment could improve treatment outcomes in cryptococcal meningitis. The gene discussed is PDCD1; the disease is Cryptococcal meningitis.