CD40LG and cancer: Other factors associated with onset of active Cryptococcus infection include the following: loss of quality multifunctional CD4 T cells among HIV‐infected individuals,49, 50 loss of IgM + memory B cells (innate‐like IgM producing memory B cells) among HIV‐infected adults,51 use of B cell‐depleting antibody therapies (rituximab and infliximab) among cancer patients,47, 52, 53 defects in the FC‐γ receptor polymorphism54, 55, 56 and fungal evasion of phagocytosis (immune escape).38, 57, 58