Of note, application of anti‐PD‐1/PD‐L1 antagonists (PD‐1 blocking antibodies) altered PD‐1‐modulated responses by promoting fungal clearance, upregulating ICOS and XO40 on Th1, Th2, Th17 and regulatory T cells while downregulating IL‐5 and IL‐10 immune regulatory cytokines in the model of cryptococcosis.73 The gene discussed is CD274; the disease is cryptococcosis.