In addition, research needs to be focused on NRP1‐specific function in the occurrence and progression of PACA, mechanism of influence of NRP1 on the proliferation, migration and metastasis of PACA, and contribution of NRP1 to the development of PACA signaling pathway.30, 31. This evidence concerns the gene NRP1 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.