Additionally, we previously showed that GIP (1–30) expression in the islet was enhanced concomitantly with the alpha cell expansion in several rodent models of diabetes and exogenous PEGylated GIP (1–30) injection ameliorated hyperglycemia without weight gain via alleviation of both beta cell death and alpha cell expansion in the low‐dose streptozotocin‐treated diabetic mice (Yanagimachi, Fujita, Takeda, Honjo, Atageldiyeva, et al., 2016). This evidence concerns the gene GIP and diabetes mellitus.