Our previous results suggested that miRNAs upregulated in DS placentas (miR-99a, miR-542-5p, miR-10b, miR-125b, miR-615, let-7c and miR-654) can potentially affect the expression of many genes crucial for intercellular communication (e.g. connexin 1), cytotrophoblast cell adhesion (cadherin 11) or syncytiotrophoblast differentiation (syncytin-1 and 2) and, thus, affect physiological placental development [29]. This evidence concerns the gene CDH11 and Dravet syndrome.