The secretion of leptin, a pro-inflammatory adipokine, increases differentiation, proliferation and the survival of cancer cells via the Janus Kinase (JAK)/Signal Transducers and Activators of Transcription 3 (STAT3), Mitogen-activated protein kinases (MAPK)/extracellular signal regulated kinases (ERK) and phosphoinositide 3-kinase (PI3K)/protein kinase b (AKT) signalling pathways4. This evidence concerns the gene AKT1 and cancer.