APOE and atherosclerosis: Considering human atherosclerosis development takes from months to years or even decades with individual variations, thus two ideal strains of mice, ApoE−/− and LDL receptor deficient (Ldlr−/−) mice, to study the atherosclerosis are established, which are susceptible to develop atherosclerotic lesion formation during high-fat or high-cholesterol diet and several features of the disease mimic to humans42.