Although both strains develop features of type 2 diabetes and promote atherosclerosis development, Ldlr−/− mice are more prone to develop diabetic phenotype including increased body weight, subcutaneous fat accumulation, high blood glucose, and developed an insulin resistance compared to the ApoE−/− mice and the control wild-type mice during HFD challenge43. This evidence concerns the gene APOE and type 2 diabetes mellitus.