The beneficial of HFD-induced atherosclerotic mouse model than spontaneously developing atherosclerotic lesions by SCD-fed ApoE−/− mouse model is that HFD can accelerate the progression of atherosclerosis and also elevate AST and ALT levels (Supplementary Fig. 1A,B) to increase the risk of developing CVD. Here, GPT is linked to Schnyder corneal dystrophy.