The correlated changes in Foxp3 and CTLA-4 expression in and of CD4+ T cells, CD86 expression of myeloid dendritic cells and several COX-controlled LM in NEDA patients and their absence in EDA MS patients with higher COX-controlled LM levels could also indicate the involvement of another dioxygenase in active RR-MS patients. This evidence concerns the gene CD4 and myeloid sarcoma.