Of those, nine are cancer-related genes from any cancer type annotated as a driver, drug target, kinase, oncogene, or tumor suppressor (Fig. 2a), including FGFR3 (12 samples), MAPKAPK2 (5), MYC (19), NTRK1 (3), PAX5 (3), PIM3 (3), RARA (3), TXNIP (7), and WHSC1 (97)21. Here, NSD2 is linked to cancer.