Aprepitant had no effect on urinary cortisol level (p = 0.18) nor on plasma cortisol (p = 0.89) and ACTH (p = 0.43) levels in basal condition or in response to hypoglycaemia stress (Fig. 6a–c; Supplementary Discussion; Supplementary Figs. 7 and 8). The gene discussed is POMC; the disease is Hypoglycemia.