Although most of the lncRNAs regulate none or merely a single sepsis module (Fig. 5b), FENDRR, MALAT1, TUG1, CRNDE, and ANCR connect multiple sepsis modules with the connectivity of 14, 10, 10, 8, and 5, respectively, which are expected to have high potentials to be involved in the sepsis progress (Additional file 3). This evidence concerns the gene TUG1 and Sepsis.