CCL2 and neoplasm: Moreover, the formation of invasive squamous cell cancer and the associated production of CCL2, GM-CSF, M-CSF (Macrophage colony-stimulating factor) and TNF (Tumor Necrosis Factor) caused by conditional deletion of the gene encoding p120 catenin in mice resulted in the accumulation of immunosuppressive CD11b+GR1+CD124+ MDSCs, which activated stromal fibroblasts and promoted tumor progression [118].